Formulation and optimization of clotrimazole nail lacquer as transungual drug delivery system

Journal Of Advanced Pharmacy Education And Research 2026 Open access

Read full text
Authors: Roaa A. Nief, Ahmed Yousif Fadhel, Ghufran H. Mahmood, Ashti M.H. Saeed, Mohammed Layth ‎Hamzah, Fatimah Waleed Tarkan, Tabarak Qais, Zeena Ali Khalaf, Dhuha Abdulazeez Shihab, Hawrah Emad Salamah, Batool Salah Muhi, Dhuha Nadhum Maajel
DOI: 10.51847/6acu1pfl8l
Cited by: 0
References: 35

Abstract

Clotrimazole nail lacquer was created using this research, which also included the incorporation of two different kinds of polymers. (Eudragit RL 100 and ethyl cellulose) in various concentrations, as well as castor oil as a plasticizer, salicylic acid as a keratolytic agent, and N-acetylcysteine as a penetration enhancer. The objective was to optimize the selection of polymers and their concentrations to enhance release efficacy based on in vitro permeability experiments, while also ensuring fa

Fields of Study & Subjects

Advancements in Transdermal Drug Delivery Nail Diseases and Treatments Advanced Drug Delivery Systems

Publication details

Journal / source
Journal Of Advanced Pharmacy Education And Research
Volume
16
Issue
1
Pages
73–79
Publication date
1 January 2026
Language
EN