The Neuroprotective Effects of Simvastatin in Doxorubicin-Induced Brain Toxicity in Rats
Abstract
Lipophilic statins (e.g., simvastatin (SMV)) played a cytoprotective role against various injuries via mitigating neuroinflammation and attenuating oxidative damage. Doxorubicin (Dox) leads to tissue injury, particularly cardiotoxicity and brain toxicity. The present study aimed to investigate the neuroprotective potential of SMV against Dox-induced neurotoxicity in rats. A total of 56 Albino Wistar rats were housed in cages and subclassified into control male and female groups, Dox male and fem
Fields of Study & Subjects
Chemotherapy-induced cardiotoxicity and mitigation
Cancer-related cognitive impairment studies
Cancer
Lipids
and Metabolism
Publication details
- Journal / source
- Journal Of Biochemical Technology
- Publisher
- Polaris
- Volume
- 17
- Issue
- 1
- Pages
- 20–26
- Publication date
- 1 January 2026