Predicting Long-Acting Injectable Release Using Polymer Degradation, Drug Loading, and Microsphere Morphology
Abstract
Long-acting injectable microspheres are an important platform for sustained drug delivery because they can maintain therapeutic exposure over extended dosing intervals. Their release behavior remains difficult to predict because polymer degradation, drug loading, and microsphere morphology interact across burst, lag, and erosion-controlled phases. Current formulation development often depends on empirical iteration, in which candidate batches are manufactured and tested before mechanistic unders
Fields of Study & Subjects
Advanced Drug Delivery Systems
Drug Solubulity and Delivery Systems
Nanoparticle-Based Drug Delivery
Publication details
- Journal / source
- Pharmacophore
- Publisher
- Polaris
- Volume
- 17
- Issue
- 1
- Pages
- 33–42
- Publication date
- 1 January 2026