Hematological indices in patients with varying degrees of coronary artery atherosclerosis

Despite the successes of preventive cardiology associated with effective impact on modifiable risk factors of heart diseases, the main cause of death worldwide remains coronary heart disease. The development of atherosclerosis is based on the violation of lipid metabolism and local inflammation of the vascular wall. Hematological indexes may be new marker in predicting the severity of atherosclerotic lesion of the coronary arteries. Purpose. To compare the hematological indices in patients with atherosclerosis of the coronary arteries of varying severity. Material and methods. The study included 88 patients who were divided into three groups: without coronary artery atherosclerosis (n = 31), with non-stenotic coronary artery atherosclerosis (n = 26), and with stenotic coronary artery atherosclerosis (n = 31). The average age of the patients was 58.5±7.9 years. The following hematological parameters were determined: NLR (neutrophil-lymphocyte ratio), PLR (platelet-lymphocyte ratio), MLR (monocyte-lymphocyte ratio), SII (systemic inflammation index). SIRI (Index of systemic inflammatory response). The data obtained was processed using the statistical packages Excel, Statistica 10.0. Results. The SIRI hematological index was significantly higher in the group of patients with coronary artery stenosis compared with patients with non-stenosing coronary artery atherosclerosis (1.20 (0.96; 1.74) and 0.85 (0.66; 1.21), respectively, p < 0.007) and patients without coronary artery atherosclerosis (1.20 (0.96; 1.74) and 0.77 (0.54; 1.21), respectively, p < 0.002). The NLR was also higher in the group of patients with stenotic coronary artery atherosclerosis compared to patients without coronary artery atherosclerosis (2.03 (1.67; 2.74) and 1.54 (1.33; 2.03), respectively, p < 0.007). Conclusion. Hematological indexes, along with traditional risk factors, can become promising and economically accessible biomarkers in routine practice, used in the prediction of the severity of coronary atherosclerosis and the stratification of cardiovascular risk. The introduction of the use of hematological indexes as additional criteria of prognostic models is of scientific and practical interest and requires further study.