ASSOCIATION OF PLASMA ALDOSTERONE LEVELS IN STAGE II HYPERTENSION PATIENTS WITH INDICATORS OF INSTRUMENTAL RESEARCH METHODS

The aim of the study was to determine the associations of plasma aldosterone content in patients with stage II hypertensive disease with the indices of instrumental methods of investigation.A total of 120 patients with stage II hypertensive disease were examined (defined according to the recommendations of the European Society of Hypertension, 2023, as well as the Clinical protocol of primary and specialized medical care for patients with hypertensive disease, 2024) with and without concomitant chronic coronary disease (defined according to invasive coronaroventriculography data) and frequent ventricular extrasystole (verified according to Holter electrocardiogram monitoring data).The mean age of the examined patients was 57,3±0,9 years.Echocardiography was performed in all patients.Four groups of patients were distinguished (30 in each): the first grouppatients with hypertensive disease without concomitant chronic coronary disease and ventricular extrasystole, the secondpatients with hypertensive disease and frequent ventricular extrasystole, the thirdpatients with hypertensive disease and concomitant chronic coronary disease, the fourthpatients with hypertensive disease and concomitant chronic coronary disease and frequent ventricular extrasystole.The aldosterone content in EDTA plasma of blood was determined by enzyme immunoassay using the commercial kit "Aldosterone ELISA" ("DiaMetra", Italy) in accordance with the manufacturer's instructions.Statistical analysis of the obtained results was performed using methods of variational statistics with the use of Microsoft Excel (2019) and Statistica 12.0 (Statsoft, USA).Using the method of variational statistics it was found that the plasma aldosterone content in the examined cohort of patients (n=120) is in the range of 42,8-285,0 pg/mL, the mean value is 158,1±55,5 pg/mL (the median of the index is 152,5 pg/mL, the interquartile range is 116,5 and 204,5 pg/mL).In order to perform analytical comparisons, the aldosterone index was dichotomized according to the median.The rounded value of the median of the marker (153,0 pg/mL) was taken