The Impact of the Drug Losartan on a Few Biochemical Indicators in Wistar Albino Male Rats with Isoproterenol-Induced Heart Infarction

Objective: Cardiovascular disease (CVD) remains a leading cause of death and disability worldwide. This study investigated the therapeutic and preventive effects of losartan on myocardial infarction in male albino rats. Methods: Cardiac infarction was induced in 100 rats using subcutaneous isoproterenol (65 mg/kg/day) for five days. Rats were divided into two main groups: Group 1 received isoproterenol only, while Group 2 was subdivided into four subgroups, including a losartan-pretreated group (losartan for 55 days prior to isoproterenol). Biochemical markers, including troponin, CK-MB, angiotensin II, glutathione (GSH), and total protein, were measured. Results: Isoproterenol significantly increased troponin, CK-MB, and angiotensin II (p