Management Of Female Pattern Hair Loss (FPHL) Using Autologous Mesenchymal Stem Cells: Report Of Two Cases

Background and objective: The cause of FPHL in young women remains elusive. Many conventional treatments often fail because of the complexity and failure to diagnose the cause. We report here two young women who were treated with bone-marrow-derived autologous Mesenchymal Stem Cells (MSCs) and their Extracellular vesicles (EVs) for FPHL. Methods: Under local anesthesia and sedation 40 ml of autologous bone marrow was aspirated from iliac crest and mesenchymal stem cells were cultured. One million per kg body weight was injected at multiple sites in scalp area of hair loss using 30 gauge needle. Fifty million Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) was added to to 50 ml of 1% glyecrine and was given in a metered dose of 2 ml of the gel was applied to the scalp area daily. Results: There were no adverse effects due to the treatment, and within six months, there was significant regrowth of the hair in both patients in areas of intradermal injection and surrounding areas. Conclusion: MSCs and MSC-derived EVs treatment is a potential and successful method to treat FPHL, which does not respond to conventional management. Early intervention will save from psychological distress and depression in young women.