Сhronic Venous Disease as Part of Continuum of Cardiovascular Disease – Shared Pathophysiology, Risk Factors and Novel Pharmacological Treatment Paradigms

Chronic venous diseases (CVeD) are widely recognized as serious medical and social problems.They are a common, progressive group of diseases that have a significant negative influence on patients' quality of life and put an immense burden on healthcare systems around the world.An increasing number of studies in recent years have indicated that CVeD is more than just a local vein concern.Instead, it may sit on a broader cardiovascular continuum-reflecting systemic vascular dysfunction, sharing many of the same risk factors, and potentially flagging a higher risk of serious cardiac events.Both CVeD and cardiovascular diseases (CVDs) involve endothelial dysfunction, systemic inflammation, and oxidative stress.All these mechanisms are interconnected and mutually mediate.There is a need for a better understanding of the biological pathways shared by CVeD and other cardiovascular diseases to prevent and treat them more effectively.Understanding these common mechanisms can help develop new treatments that improve outcomes for both conditions, as well as more integrated preventive strategies.New research will be needed to prove, on the one hand, that modern pharmacotherapy of chronic venous diseases has not only regional but also systemic significance and, on the other hand, based on the similarity of pathogenesis, that in these diseases, neurohormonal and other therapies can also have the same beneficial effect as in several cardiovascular diseases.