Evaluation of the Relationship Between Serum C-Reactive Protein, Urinary Albumin-to-Creatinine Ratio and Lipid Profile in Patients with Diabetes

Background: This study looked at the levels of a protein called C-reactive protein (CRP), a kidney marker called urinary albumin-to-creatinine ratio (ACR), and blood fats (lipid profile) in people with diabetes to see how they are related. Methodology: We studied 150 people with diabetes divided into three groups of 50 each: Group I had diabetes for less than 5 years, Group II for 5 to 10 years, and Group III for more than 10 years. We tested their blood fats, CRP, and ACR levels. Results: Analysis showed significant differences across all groups for all parameters (P < 0.05). Comparing Group I to Group III, hs-CRP increased from 0.34 ± 0.02 mg/dl to 0.95 ± 0.17 mg/dl (a 179.4% increase) and ACR rose from 100.4 ± 12.2 to 127.5 ± 12.5 (a 27.0% increase). Lipid parameters also showed an upward trend from Group I to Group III: Triglycerides increased from 219.4 ± 25.8 mg/dl to 260.3 ± 27.8 mg/dl (18.6% increase), Total Cholesterol from 208.5 ± 35.2 mg/dl to 233.3 ± 27.1 mg/dl (11.9% increase), and LDL from 132.5 ± 30.4 to 145.2 ± 37.5 (9.6% increase). HDL showed a slight rise from 48.2 ± 4.5 to 50.1 ± 4.9 (3.9% increase). Pearson correlation confirmed that hs-CRP was significantly associated with ACR in all groups. Conclusion: People who have had diabetes for a longer time tend to have higher levels of CRP and ACR. Key words: C-reactive protein, diabetes, lipid profile.