The Synergistic Potential of Copper Nanoparticles and Saccharum Officinarum Phytochemicals in the Modulation of Neurodegeneration in Parkinson’s Disease: Insights from Siddha Inspired Approach

Parkinson’s disease (PD) is a neurodegenerative disorder marked by oxidative stress, neuroinflammation, and α-synuclein aggregation, leading to dopaminergic neuron loss. This study explores the therapeutic potential of copper nanoparticles (CuNPs) and Saccharum Officinarum phytochemicals, leveraging their antioxidant and neuroprotective properties. Analyses of articles revealed that CuNPs reduce oxidative stress, inhibit α-synuclein aggregation, and downregulate pro-inflammatory cytokines, improving motor function and neuron survival. Combining Siddha medicine with nanotechnology, CuNPs show promise as a PD treatment. Further research is needed to optimize clinical applications and delivery methods for enhanced therapeutic efficacy. Keywords: Copper nanoparticles (CuNPs), Saccharum Officinarum, Parkinson’s Disease, Siddha Medicine..