Antibiotic resistance of pathogens causing urinary tract infections in cats and dogs

The monitoring of antibiotic resistance of urinary tract infections (UTI) in cats and dogs is a critical step for effective antibacterial treatment of UTIs. This study evaluated the sensitivity of 480 strains presented by Escherichia coli , Proteus mirabilis , Klebsiella pneumoniae , Staphylococcus spp ., all isolated from animal urine. Identification was performed by MALDI-TOF mass-spectrometry, and sensitivity to antibiotics and mechanisms of resistance were determined by disc diffusion and molecular genetic methods in accordance with the EUCAST recommendations. Significant differences between different types of bacteria were identified: K. pneumoniae had the highest frequency of resistance (42.9%), with 28.6% of resistant strains showing resistance to beta-lactams and carbapenems. The ESBL production was the predominant mechanism for E. coli (19.7% of 20.4% resistant isolates), while carbapenemase was found in only 0.7% of isolates. P. mirabilis had the lowest resistance rate (10.6%) and only exhibited beta-lactam resistance. Methicillin resistance was found in 13.9% of Staphylococcus spp., 93.3% of which were represented by S. pseudointermedius (MRSP). The data obtained confirms the need for the identification of UTI pathogens and their sensitivity to choose an appropriate antimicrobial therapy.