Methylprednisolone in the pathogenesis of inflammatory lesions of the central nervous system associated with microorganisms of the genus Acinetobacter (A. radioresistens, A. baumannii) in dogs

The article presents the results of a study on the inflammatory process in the central nervous system (CNS) of dogs in which the microorganism Acinetobacter radioresistens was isolated from cerebrospinal fluid based on bacteriological analysis. Clinical manifestations are described, as well as data from X-ray examination, MRI, and cytological examination of cerebrospinal fluid. The pathogenesis of inflammation and edema is determined, along with the therapeutic effect of methylprednisolone (Medrol). It is noted that A. radioresistens can act as an etiologic agent for neuroinfections and a potential reservoir of resistance genes similar to those found in A. baumannii . Damage to the blood-brain barrier and the pathogenetic rationale for using glucocorticoids in cases of CNS inflammation in dogs are discussed.