Dopamine and Serotonin in Schizophrenia: A Comparative Theoretical Study.

Neurotransmitters are signaling molecules that travel across the synaptic space to interact with receptors. In this study, the relationship between serotonin and dopamine was highlighted in schizophrenia. Serotonin and dopamine have individual roles in the progression of the disease, but interesting results have focused on an interactive role. Earlier research works have highlighted that the serotonin system inhibits the dopaminergic function at the level of origin of the dopamine system in the mid-brain as well as at the terminal dopaminergic field in the fore-brain. To conclude, the therapeutic success of clozapine and risperidone have revealed that two systems act as an avenue for superior therapeutic actions in schizophrenia.