Gastro-Protective Role of Solanum Aethiopicum Ethanol Extract in Potassium Bromate-Induced Toxicity in Rats

This study was aimed at investigating the gastroprotective role of Solanum aethiopicum ethanolic extract on lipid profile in potassium bromate-induced toxicity in Wistar rats. The treatment lasted for 28 days. Thirty-five (35) rats weighing 140 g-150 g were used in this study and were separated into five groups of 7 rats. Groups 3 ,4 and 5 were pre-teated with 50 mg/kg of potassium bromate for 2 weeks. Group 1 (control) was given normal feed and 0.2 ml of normal saline. Group 2 was administered 50 mg/kg of potassium bromate for 2 weeks. Groups 3 and 4 received 300 mg/kg and 600 mg/kg of Solanum aethiopicum extract, respectively. Group 5 was administered 100 mg/kg of Vitamin C. After 28 days of administration, the animals were subjected to fasting for 24 hours and were anesthetized and sacrificed, and blood was collected by cardiac puncture, spinned and the serum used to carry out tests for lipid profile. In another set of fifty (50) male Wistar rats (150–190 g), they were randomly divided into five groups and were sacrificed to access pepsin activity and mucus secretion. Juice collected from the stomachs was also subjected to pH, pepsin activity and total acidity tests. Low doses (significantly P