Disseminated Paracoccidioidomycosis with Osteoarticular and Miliary Pulmonary Involvement: A Case Report
Abstract
Paracoccidioidomycosis (PCM) is a systemic fungal infection endemic in Latin America, primarily affecting the lungs and mucocutaneous tissues. Osteoarticular involvement is uncommon and may mimic bacterial or mycobacterial diseases. We describe a disseminated PCM case in an immunocompetent 37-year-old woman presenting with ankle monoarthritis and diffuse miliary pulmonary infiltrates. Histopathology confirmed multiple-budding yeast forms of Paracoccidioides spp., while cultures and serological tests were negative. The patient was treated with liposomal amphotericin B followed by oral itraconazole, achieving complete clinical and radiological recovery. PCM should be considered in endemic regions when musculoskeletal lesions coexist with pulmonary findings, even in immunocompetent hosts.
Fields of Study & Subjects
Fungal Infections and Studies
Nail Diseases and Treatments
Antifungal resistance and susceptibility
Publication details
- Journal / source
- Brazilian Journal of Case Reports
- Publisher
- Publicacoes Cientificas de Acesso Aberto e Editora LTDA
- Volume
- 6
- Issue
- 1
- Pages
- bjcr144–bjcr144
- Publication date
- 4 January 2026