Design, Development and Evaluation of Irbesartan Fast Dissolving Buccal Films

The primary goal of this effort is to create quickly dissolving buccal films for the low-soluble anti-hypertensive drug Irbesartan.Polyvinyl alcohol, HPMC E5, and polyethylene glycol 400 are used as plasticizers and film-forming agents to create the films. Weight, thickness, surface pH, homogeneity of drug content, swelling index, curling, in-vitro residence time, folding endurance, and in-vitro dissolution and penetration investigations were all assessed for the films. Formulation F4 demonstrated quicker absorption and favorable film properties, releasing up to 98.29% of the medication in 5 minutes. Research on the possible interactions between medications and excipients that are used in film preparation revealed no meaningful interactions. Because of their potential regulated drug release, manageable residence time, and successful enlargement, the films were selected for effective therapeutic applications.