Development of Composition and Technology of Anti-Fungal Gel with Ferula songarica Essential Oil Growing In The Territory Of Central Kazakhstan

We have studied the chemical composition of the essential oil of Ferula songarica and the antifungal activity of the underground part of Ferula songarica growing in the vicinity of Karkaralinsk, Karaganda region. It was revealed that the main components of this oil are pinene - 32.91% and 3-octene-5-ene-2,7-dimethyl-, (E)-19.47%. As a result of a study on antifungal activity, it was found that Ferula songarica essential oil and gel based on Ferula songarica essential oil have a pronounced antifungal effect against clinical strains of yeast fungi C. albicans, C. dubliniensis and C. glabrata. The article presents the results of the development of the composition and technology of an antifungal gel based on the essential oil of Ferula songarica, growing in Central Kazakhstan. Research has been conducted to select the optimal gel base to ensure the stability and therapeutic effectiveness of the drug. The optimal formulation parameters, including the concentration of essential oil (3%), were experimentally determined, and its high antifungal activity against strains of the yeast fungi C. albicans, C. dubliniensis and C. glabrata was confirmed. The rheological properties of the gel have been investigated, and the characteristics that ensure the convenience of application and restoration of the structure after mechanical action have been identified. The developed gel production technology ensures the stability of physico-chemical properties and microbiological purity throughout the shelf life.