A Mild and Efficient method for the Synthesis of Diversified Isoquinolines and β-carbolines from N-tosyl-THIQs and N-tosyl-THBCs: Benefit in the total synthesis of 3,4-dihydropapaverine, harmane and Eudistomin U
Abstract
It is easy and effective to obtain a range of isoquinolines and β-carbolines and their natural derivatives, including 3,4-dihydropapaverine, Harmane, and Eudistomin U, via β-elimination and aromatization. Additionally, this protocol works well in the synthesis of partially dehydrogenated isoquinolines at a good yield.
Fields of Study & Subjects
Synthesis and bioactivity of alkaloids
Synthesis and Biological Activity
Advanced Synthetic Organic Chemistry
Publication details
- Journal / source
- Research Journal of Pharmacy and Technology
- Volume
- 19
- Issue
- 1
- Pages
- 137–137
- Publication date
- 13 January 2026