Mechanistic Pathways Linking Maternal PUFA Status with Gestational Length: The Mediating Roles of Inflammation and Sleep Quality

Introduction: The following study has discussed the Maternal polyunsaturated fatty acids (PUFAs), mainly the docosahexaenoic acid (DHA) to arachidonic acid (AA) ratio, that plays a critical role in fetal growth and gestational well-being. Imbalances in omega-3 and omega-6 fatty acids can influence inflammatory paths and sleep quality, which are important causes of gestational length and pregnancy results. Aim: The aim of this study is to investigate the mechanistic paths connecting maternal PUFA status with gestational length, focusing on the mediating effects of inflammation and sleep quality. Method: This cross-sectional observational study involved 100 pregnant women, grouped by their RBC DHA:AA ratios into High PUFA (≥4.0) and Low PUFA (