New UV Spectrophotometric Method by Using Surfactant as Solubilizing Agent for Determination of Anti-Covid-19 (Ivermectin) in Dosage Form

The current study presents a simple, quick, accurate, precise, and affordable approach for the determination of Ivermectin in tablet dosage forms. The developed method based on UV Spectrophotometric analysis at Zero-order without any separation step or any sophisticated previous step. The described approach uses Sodium Lauryl Sulfate (SLS) Solution (0.5%) as a solvent. Ivermectin (IVR) exhibited maximal absorbance at 245 nm, with linearity throughout concentration ranges of 2.5-25 μg mL-1. The mean percentage recovery was 99.5% and the precision was within the relative standard deviation of less than 2%. The approach was effectively utilized to determine the medication in tablet preparation. The results of the selectivity test demonstrated that the tablet excipients did not interfere with the separation process, confirming that this approach is not only quick, accurate, and economical, but also easily adaptable to quality control labs and the pharmaceutical industry. The approach was validated in accordance with the recommendations of the International Council for Harmonization.