Explore the Antidiabetic Potential of Sechium edule: Ethanol Extract's Impact on Apoptotic Markers Caspase-3, Caspase-8, Bcl-2, and Bcl-xL in Type II Diabetic Rats

Introduction: Type 2 diabetes mellitus is highly associated with apoptosis The several causes of T2DM include insulin resistance caused by obesity, inadequate insulin synthesis, and loss of -cell mass owing to -cell death. The ratio of pro- and anti-apoptotic Bcl-2 proteins (Bad, Bid, Bik, and Bax) to apoptosis is mostly responsible for hyperglycemia-induced cell death. Sechium edule is pharmacologically recognized to lower blood glucose in rats. Objective: to examine apoptosis parameters in rats with type II diabetes. Method: This study was divided into six groups: control, diabetic rats, positive control, treatment I (50 mg/kgbw extract), treatment II (100 mg/kgbw extract), and treatment III (mg/kgbw extract). All rats were sacrificed at the conclusion of the research, and their blood was collected for further analysis of caspase-3, caspase-8, Bcl-x, and Bcl-2. Results: showed that pro apoptotic parameters such as caspase-3, caspase-8, and bcl-xl concentration were significantly reduced (p