Fabrication and Evaluation of Itraconazole Particulate Drug Delivery System

The aim of the research was to design and test Itraconazole loaded nanoparticles drug delivery system, as the Itraconazole nanoparticles of appropriate size ranges are likely to enhance the therapeutic and toxicity reduction effects of this wide-spectrum antifungal agent. The loading of Itraconazole nanoparticles was done through Emulsification and Solvent Evaporation. Optimized ratios of excipients were also conducted in which the ratio of drugs-lipid and the ratio, surfactant-cosurfactant (Km) were adjusted to optimize the formulation properties. The zeta potential measurement and the analysis of the particle size were performed using Malvern Mastersizer Hydro 2000G. The in vitro release profile of nanoparticles showed to have a maximum release profile of 12h. The nanoparticle preparation methodology was a microemulsion mediated process that included high drug loading (ca. 80%), low and narrow size distribution and offered a reproducible and a rapid method of production. The article expounds the viability and the appropriateness of lipid based colloidal drug delivery system, using optimize design to create a clinically beneficial nanoparticle system, having targeting capabilities.