Formulation of Mupirocin Loaded Aloe Vera Transdermal Patch

In this study Mupirocin loaded aloe vera transdermal patch was prepared for enhancing the anti-bacterial activity by phytoconstituents of aloe vera gel. Mupirocin and aloe vera gel both have anti-bacterial property so, glycerine, sodium alginate aloe vera gel were blended together for the production of film base and further mupirocin was incorporated. Aloe vera transdermal patches loaded with natural polymers were created using the solvent casting process, and their physical characteristics, thickness, folding endurance, tensile strength, swelling index, percentage of drug content, and in-vitro drug release were assessed. These films demonstrated excellent characteristics in strength ranging from (0.36-0.45 kg/cm2), thickness (120-159 mm), % drug content (67.18-82.86), in-vitro drug release (78-97%) and properties of hydrophilicity.