Fabrication and Characterization of Novel Repaglinide Incorporated Buccal Film for the Management of Type-2 Diabetes
Abstract
A study was conducted on repaglinide, an antihyperglycemic agent, used in the management of non-insulin-dependent diabetes mellitus, to design and characterize bioadhesive buccal films to overcome hepatic first-pass metabolism. The films are prepared using various ratios of bioadhesive polymers like HPMC, chitosan, and carbopol. For elucidating the physicochemical compatibility between the drug and the used polymers, FT-IR spectroscopy was employed. The prepared films were evaluated for in vitro drug release, bioadhesion strength, swelling index, moisture absorption, and surface pH.
Fields of Study & Subjects
Advanced Drug Delivery Systems
Drug Solubulity and Delivery Systems
Inhalation and Respiratory Drug Delivery
Publication details
- Journal / source
- Research Journal of Pharmaceutical Dosage Forms and Technology
- Volume
- 18
- Issue
- 1
- Pages
- 47–47
- Publication date
- 30 January 2026
- Language
- EN