Nanosponges Loaded Hydrogels for Anti-Inflammatory Drug Delivery: Characterization Evaluation and Applications

Nanosponges and hydrogels represent a novel convergence in advanced drug delivery systems. Nanosponges, with their highly porous structures, are effective at encapsulating and delivering therapeutic agents under strict control. They enhance drug solubility, bioavailability, and provide targeted delivery to reduce systemic side effects. Hydrogels, known for their three-dimensional, hydrophilic networks, complement nanosponges by offering biocompatibility, biodegradability, and stimuli-responsive controlled release. The integration of nanosponges into hydrogels synergistically combines the strengths of materials, improving drug release profiles and maintaining therapeutic levels over extended periods. This review focuses on anti-inflammatory drug delivery, highlighting the capacity of nanosponge-loaded hydrogels to deliver nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids effectively. Characterization studies, including morphological and swelling behavior analysis, confirm the system's potential for sustained and localized drug release. Therapeutic evaluations, both in vivo and in vitro, show improved efficacy and reduced side effects. The innovation offers promising applications in managing chronic inflammatory diseases, wound healing, and gastrointestinal disorders, presenting a pathway toward safer and more effective anti-inflammatory therapies.