Formulation and Evalutaion of Ethosomal Transdermal Patch of Antidiabetic Drug

Objective: The primary goal is to prepare appropriate transdermal patches of the antidiabetic medication glimepiride using varying ratios of polymers (hydroxyl propyl methyl cellulose K-100) in accordance with patient needs (patient compliance) and for superior drug release compared to alternative formulations. These formulations use ethanol and chloroform (1:1) as a solvent system and 0.2 ml of glycerol as a plasticizer. The in-vitro skin penetration experiments were conducted using a Franz diffusion cell and phosphate buffer pH 7.4. Method: A magnetic stirrer was used to prepare the transdermal patches utilizing the solvent casting process. Results: Beer's law was adhered to. between 2 and 12 μg/ml in phosphate buffer at a pH of 7.4. Linear regression equation of pure drug was established as Y=0.058x + 0.1331 and the R 2 value 0.999. Zero order release kinetics implies that the drug release of formulation GTP7 is better than that of the other formulation. Conclusion: Formulation GTP7presented a statistically insignificant change of the percent drug content and permeation profile after 90 days of studies.