Formulation Development and Evaluation of SEDDS of Poorly Soluble Drug

The objective of the present study was to develop self-emulsifying drug delivery system (SEDDS) of Sarcostemma acidum extraxt to improve its solubility, in vitro dissolution efficiencies, and further the bioavailability. The solubility of Sarcostemma acidum extract in various oils, surfactants, and cosurfactants was determined.. Prepared SEDDS was evaluated for emulsification time, drug content , in vitro dissolution and stability study . The optimized formulation had shown the maximum solubility, less emulsification time, good stability and improved in vitro release. In the present study, already existed historical data were used for importing data It was concluded that SEDDS would be a promising drug delivery system for poorly water-soluble plant extract through oral route. DOI: https://doi.org/10.52783/jchr.v16.i1.12270