Formulation, Development and Evaluation of SEDDS of Andrographic Paniculata Plant Extract

Leave and aerial (whole parts) of Andrographic paniculata have anti-inflammatory and antidiabetic efficacy. However, the clinical translation of plant extracts is often hindered by poor aqueous solubility and low oral bioavailability,. The Self-Nanoemulsifying Drug Delivery System (SNEDDS) offers a promising approach to overcoming these limitations by enhancing solubility, stability, and gastrointestinal absorption of lipophilic phytoconstituents. In order to increase Andrographic paniculata extract's solubility, in vitro dissolving efficiency, and bioavailability, the current work set out to design a self-emulsifying drug delivery system (SEDDS). Andrographic paniculata extract's solubility in a range of oils, surfactants, and co-surfactants was assessed. The prepared SEDDS was assessed for stability, in vitro dissolution, drug content, and emulsification time. Maximum solubility, reduced emulsification time, good stability, and enhanced in vitro release were all demonstrated by the optimized formulation. In this investigation, data was imported using pre-existing historical data. DOI: https://doi.org/10.52783/jchr.v16.i2.12334