Predicting epistasis across proteins by structural logic

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Authors: Anowarul Kabir, Michelle Tang, Gareth A. Cromie, Amarda Shehu, Aimée M. Dudley
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Abstract

We provide the Docker Image to run IntraMutateX, the ML algorithm for predicting intragenic complementation in human ASL as described in our manuscript, “Predicting epistasis across proteins by structural logic." This Docker Image is tested only in CUDA-enabled machine. Please see the README for instructions to load and run the software. Output of the ML algorithm is included as supplemental datasets in the manuscript as well as provided in ASL_ML_plots.zip here. This software and the underlying data are available for academic use under a limited license. For commercial licensing of the data and/or the software, please contact Aimee Dudley and Amarda Shehu.

Fields of Study & Subjects

Genomics and Rare Diseases Protein Structure and Dynamics Computational Drug Discovery Methods

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
12 January 2026