Dissecting the cellular architecture of breast cancer brain metastases reveals prognostically distinct immune landscapes

Zenodo (CERN European Organization for Nuclear Research) 2026 Dataset Open access

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Authors: Lena Jassowicz, Fangyoumin Feng, Rolf Warta, Peter Lichter, Marc Zapatka, Martina Seiffert, Christel Herold-Mende
DOI: 10.5281/zenodo.17723783
Cited by: 0

Abstract

Breast cancer brain metastases (BCBM) are a severe condition with high demand for improved personalized treatment, but a comprehensive understanding of BCBM immune-microenvironment heterogeneity and susceptibility to immunotherapy is lacking. Here, we multimodally profile the immune niche in a vast, clinically annotated cohort of BCBM applying tissue cytometry, bulk and single nuclei RNA-sequencing, and spatial transcriptomics, complemented by flow cytometric and functional studies in patient-derived organoids. Here the spatial and snRNAseq data is deposited.

Fields of Study & Subjects

Brain Metastases and Treatment Cancer Immunotherapy and Biomarkers Single-cell and spatial transcriptomics

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
26 November 2026
Language
EN
Document type
Dataset