SequAna-Ukon/TrueOrtho: 2.0
Abstract
TrueOrtho 2.0 is an expanded Nextflow pipeline for automated, structural- and embedding-aware orthology identification across multiple species. In addition to traditional sequence homology and domain architecture filtering, version 2.0 integrates deep-learning structural embeddings (ESM-2), 3D structural alignment scores (Foldseek), and automated phylogenetic trees (IQ-TREE) into a unified evidence matrix.
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 4 August 2026