Lemos Lambda: Deep Science Prospector

[2.1.0] — 2026 🚀 New Features Inverted Mining Logic: System now searches 16 distant biological fields (proteostasis, microbiome, longevity, neuroprotection, gasotransmitters, resolution of inflammation, ferroptosis, mechanosensing, m6A epigenetics, etc.) without mentioning the target organ — inspired by the discovery of Trehalose and TMAO as candidates through cross-field literature reasoning. Flash Bridge (mechanism → organ): After collecting candidates from distant fields, Gemini Flash evaluates biological plausibility for the target organ. Reasoning example: "Trehalose induces autophagy and reduces ER stress — urothelium under distension experiences ER stress — worth testing." 16 Lateral Search Fields: Defined in CAMPOS_LATERAIS in the backend, covering osmolytes, specialized pro-resolving mediators (SPMs), gasotransmitters, senolytics, m6A modulators, ferroptosis, mitochondrial metabolism, and approved drug repurposing. Article Side Panel: Clicking any row in the results table opens a lateral panel with related PubMed articles. "View Abstract" Button: Expands the article abstract without consuming any AI tokens. "Investigate with AI" Button (lazy): Flash reads the article and returns [Tissue] → [Mechanism] → [Effect], called ONLY when clicked. "Investigate Target" Button (Pro, lazy): Gemini Pro performs deep analysis including mechanism, druggability, novelty score, suggested experiments, biological rationale, and red flags — called ONLY when clicked. Real-time st.status() Progress: Each mining step displays a live log (fields searched, candidates extracted, HPA check, virginity check). Expanded "Type" Column: Table now shows Receptor / Drug / Modulator / Gene / Ion Channel / Enzyme / Pathway / Biomarker. Human Protein Atlas (HPA): Integrated to verify target expression in the specific tissue of the target organ. ClinicalTrials.gov Integration: Fetches compounds in active trials for other indications (repurposing candidates). OpenTargets Integration: Fetches genetically validated targets. Orbitron Font Logo: New sci-fi logo with green glow effect. PubMed Syntax Tooltip: Help icon on the Main Target field explains OR, NOT, AND operators with examples. Expanded Presets: New categories — Autophagy & Metabolism, Vasculature & Fibrosis, Microbiome & Metabolites. biologicalRationale Field: Investigation JSON now includes an explanation of why the target makes sense in the organ even if never tested there. Wide Funnel: Returns up to 100 candidates instead of 16–20, letting the scientist decide. 🐛 Bug Fixes Article card overflow: Fixed article titles breaking outside the card container (overflow:hidden, word-wrap:break-word). 4-minute frozen screen: Mining now shows real-time progress via st.status() — no more blank waiting. Version label: Corrected from v3.2 to v2.1. 🔧 Improvements Flash prompt completely rewritten: Perspective of a senior pharmacologist hunting for unexplored opportunities, with explicit instructions for cross-organ translational potential, animal-model-testable compounds, and "when in doubt — KEEP IT" criterion. Zero tokens during statistical analysis: No AI calls during Lambda Score calculation — Flash only called once for classification and on-demand per article. Expanded blacklist: Added academic text transition words (multivariate, ameliorate, coordinate, alleviate) and genomic noise patterns (lncRNAs, pseudogenes, antisense RNAs) via LIXO_REGEX.