PHARMACEUTICAL AND THERAPEUTIC REVIEW OF PANCHAMULADI GHRITA – AN AYURVEDIC AND MODERN PERSPECTIVE

Ghṛita Kalpana (medicated ghee preparations) represent one of the most significant dosage forms in Ayurveda. Among these, Panchamuladi Ghṛita is traditionally used in the management of Grahaṇi Roga and Vata-kaphaj disorders. This review aims to analyze the pharmaceutical aspects, classical references, and modern pharmacological relevance of Panchamuladi ghrita. The formulation, composed of Panchmula (Bilva, Agnimantha, Shyonaka, Patala, Gambhari) along with Haritaki, Vyosha, Pippalimula, Saindhava, and other digestive and anti-inflammatory herbs, processed in ghee with acidic media such as Sukta or Matulunga swaras, exhibits deep intestinal action. Modern evidence suggests that ghee-based Ayurvedic formulations enhance drug bioavailability and have mucosal healing potential. The present review concludes that Panchamuladi Ghrita is a potent Ayurvedic preparation for gastrointestinal disorders with promising scope for further pharmacological and clinical research.