CURRENT PERSPECTIVES ON CLEANING VALIDATION: TECHNIQUES AND PRACTICES ACROSS MULTIPLE SURFACE TYPES

In the food, biotechnology, and pharmaceutical industries, cleaning validation is an essential part of quality assurance since it guarantees that manufacturing equipment is clear of residues that can contaminate later batches. The procedures and analytical techniques used to find residues on a variety of surface types, such as stainless steel, glass, rubber, acrylic, aluminum, bronze, Teflon, PVC, polypropylene, titanium, ceramic, and electro shield plates, are highlighted in this review, which offers an updated overview of cleaning validation strategies. The function of surface material in residue recovery, sampling strategies including swab and rinse methods, and the choice of suitable analytical instruments like HPLC, TOC, UV-Vis, and LC-MS/MS are all covered in the article. The significance of surface-specific recovery investigations, technique validation, and regulatory expectations are emphasized. The review's objective is to assist experts in creating reliable cleaning validation procedures that are suited to a variety of equipment surfaces.