POLYHERBAL GEL-BASED TREATMENT FOR RHEUMATOID ARTHRITIS FORMULATION, CHARACTERIZATION, AND EVALUATION

Herbal plants such as Carica papaya, Tamarindus indica, Calotropis gigantean, Cardiospermum halicacabum and Cympbopogan citratus which have long been known to be a very important source of pharmaceutical properties. The study examined the anti inflammatory effect of polyherbal gel in vitro. Denaturation of proteins is the main cause of inflammation. The anti-inflammatory properties of polyherbal extract were studied at 500, 250, 100, 50 and 5 μg/mL using an albumin denaturation assay and proteinase inhibition assay. The free radical scavenging activity of polyherbal extract was evaluated by DPPH assay. The results showed that the anti-inflammatory activity of a gel based polyherbal extract shows a strong inhibition value at of IC 50 53.27 μg/ml, and Proteinase 156.2 μg/ml respectively. This study provides an evidence that the polyherbal gel possesses anti- inflammatory and antioxidant activity. That can be used for the treatment of Rheumatoid arthritis.