SAMPRAPTI BASED APPLICATION OF USAKADI GANA IN POLYCYSTIC OVARIAN DISEASE

Introduction: Polycystic Ovarian Disease (PCOD) is a prevalent endocrine–metabolic disorder among women of reproductive age, characterized by chronic anovulation, hyperandrogenism, insulin resistance, and metabolic disturbances. From an Ayurvedic perspective, PCOD can be correlated to a Kapha–Meda pradhana Santarpanajanya Vyadhi associated with Avarana of Apana Vata and Artavavaha Srotodushti. Classical Ayurvedic texts describe several drug groups (Gana) targeting metabolic obstruction and Srotorodha, among which Usakadi Gana, enumerated by Acharya Susruta, holds therapeutic relevance in Kapha–Meda dominant disorders. Objective: The present article aims to evaluate the potential role of Usakadi Gana in the management of PCOD based on Samprapti (pathogenesis), classical indications, and contemporary scientific insights. Materials and Methods: A comprehensive review of classical Ayurvedic texts, primarily Susruta Samhita, was undertaken to analyze the composition, properties, and indications of Usakadi Gana. Relevant modern literature was reviewed from databases such as PubMed, Google Scholar, and standard gynecology textbooks to understand the contemporary pathophysiology of PCOD. Results: The pharmacodynamic attributes of Usakadi Gana, including Ushna Virya, Lekhana, Chedana, Bhedana, Kapha–Medohara and Artava-sanjanana properties, appear suitable for addressing Agnimandya, Srotorodha, and metabolic dysregulation implicated in PCOD. Conclusion: Usakadi Gana demonstrates significant conceptual potential in addressing the underlying Samprapti of PCOD. Its integrative application warrants further clinical and experimental validation.