Effects of fungus extract Pestalotiopsis microspora (Speg.) Bat. & Peres, 1966, on the antioxidant system of mice infected with Plasmodium berghei Vincke & Lips, 1948

The experiment is focused on evaluating the effect of Pestalotiopsis microspora on the antioxidant system of mice infected with Plasmodium berghei. Twenty-five male albino mice of average weight of 20kg were distributed randomly into 5 groups. Infected untreated (group 1), Infected untreated (group 2), Infected treated with chloroquine (group 3) Infected treated with 25 mg/kg fungus extract (group 4), Infected treated with 50 mg/kg fungus extract (group 5). All the groups were infected with Plasmodium berghei via the intra-peritoneal route. After seven days’ post infection, infected treated with chloroquine (group 3) Infected treated with 25 mg/kg fungus extract (group 4), Infected treated with 50 mg/kg fungus extract (group 5) were treated with chloroquine, 25 mg/kg and 50 mg/kg fungus extract respectively. The treatment lasted for 4 days. The results of this study revealed that, the effect of the fungus extract significantly increased the ALT, catalase, MDA, uric acid and XO in serum of infected treated group when compared with the decrease in the uninfected untreated group.