CMEM Framework Application: E ≥ G Diagnostic Analysis of Biological Regulation Collapse under Energy-Dominant Medical Intervention

CMEM Framework Collection Link This paper presents an application-level diagnostic extension of the CMEM (Cognition–Metabolism–Energy Model) framework, focusing on the structural imbalance that arises when external energy-dominant medical interventions exceed the intrinsic regulatory capacity of biological systems. By formalizing the condition E ≥ G—where external energy input (E) persistently overrides biological regulation (G)—the study demonstrates how long-term high-intensity interventions can elevate regulatory activation thresholds, reduce sensitivity to low-intensity adaptive signals, and impair self-regulatory recovery mechanisms. The analysis reframes the distinction between traditional biological regulation and modern chemical intervention not as a cultural or material opposition, but as a systems-level control allocation problem. It argues that loss of responsiveness to low-energy regulation does not imply inefficacy, but rather reflects structural desensitization induced by prolonged energy dominance. This work provides a non-normative, engineering-oriented diagnostic framework for understanding chronic instability in biological systems, emphasizing the necessity of restoring regulatory primacy rather than escalating external intervention intensity.