IST Experimental Interface: Observational Protocols

We outline specific, falsifiable experimental protocols to validate Information Substrate The- ory (IST). Unlike standard concordance cosmology (ΛCDM), IST predicts scale-dependent vari- ations in fundamental constants based on topological fold density. We propose three primary vectors for verification: Differential Gravitational Wave Propagation in cosmic voids, Terahertz Resonance in biological microtubules, and Bit-Depth Horizon limits in recursive AI architec- tures.