SOLUBILITY ENHANCEMENT OF TELMISARTAN BY USING SOLID DISPERSION TECHNIQUE

The present study investigates the enhancement of Telmisartan solubility through the use of the solid dispersion technique. Telmisartan, an angiotensin II receptor antagonist used for hypertension management, has limited solubility in water, leading to poor bioavailability. To overcome this challenge, solid dispersions of Telmisartan were prepared using water-soluble carriers like Polyvinylpyrrolidone (PVP), Polyethylene glycol 4000 (PEG 4000), and Poloxamer 407 via solvent evaporation method. The solid dispersions were evaluated for drug release, physicochemical properties, and tablet formulation. Dissolution studies revealed a significant increase in the dissolution rate of Telmisartan from solid dispersions compared to the pure drug, following first-order kinetics. Among the carriers tested, PEG 4000 provided the highest dissolution rate enhancement. Tablets formulated with these solid dispersions showed satisfactory hardness, friability, and rapid dissolution. The dissolution of Telmisartan was markedly enhanced with increased carrier concentration, especially in the 1:2 drug-to-carrier ratios. Fourier Transform Infrared Spectroscopy (FTIR) confirmed the absence of significant chemical interaction between the drug and carriers. These results indicate that the solid dispersion technique is an effective strategy for improving the dissolution rate and bioavailability of Telmisartan.