Development and Validation of ICCA-O (Optimized Adjusted Central Adiposity Index): A Composite Cardio-Metabolic Risk Indicator Integrating BMI, WHR, WtHR, ABSI, and BAI

The paper introduces ICCA-O as a geometric mean-based formula: ICCA-O = (BMI × WHR × WtHR × ABSI × BAI)^{1/5} × 1.50 × (0.01 × Age - 0.40) × sex_factor, categorizing risk from low (0.85). It demonstrates superior performance over individual indices via ROC analysis, correlations, and regression models on a simulated adult cohort. Sections cover methods, validation, comparisons, global applicability, examples, results, and conclusion emphasizing clinical utility.