Formulation and Evaluation of Liposome Loaded Anti-Aging Cream

Aim: The current study’s objective was to formulate and evaluate a liposome loaded anti-aging cream in order to improve the absorption and to show long lasting effect. Tinospora cordifolia and Centella asiatica was incorporated into the liposome which shows antioxidant and anti-inflammatory activity. Liposome delivery system was preferred due to its greater solubility, permeability, and bioavailability. It carries drug which shows increased drug penetration. Materials and methods: Liposome were prepared using ethanol injection method. Soya lecithin act as main phospholipid and stabilize the formulation. Cholesterol provides stability as well as it controls permeability which prevents leak out of encapsulated drug. Liposome was incorporated into cream base. Evaluation was carried out for both liposomes include zeta potential and FESEM & cream include physical appearance, homogeneity, pH, spreadability, viscosity, and washability. Results And Discussion: FTIR studies shows that the extracts and excipients were compatible with each other. Zeta potential indicates that the liposome has minimal aggregation with consistent size distribution and FESEM confirms the successful formation of liposome (particle size 141.6 nm and 176.2 nm). The cream shows white and homogenous with a soft and smooth texture. It was easily washable and spreadable. Antioxidant studies confirmed that the cream showed strong antioxidant activity. Conclusion: Liposome loaded anti-aging cream provides an effective and biocompatible platform for controlled and targeted dermal delivery of plant-derived compounds, improving therapeutic performance and cosmetic benefits.