The Effectiveness of JAK Inhibitors in Treating Adolescents

JAK (Janus Kinase) inhibitors are a class of pharmacologic agents that reduce inflammation by interrupting cytokine signaling. The objective of this review was to summarize effectiveness rates of JAK inhibitor use in selected adolescent populations. This review was conducted through a literature search through databases including PubMed and Google Scholar to identify relevant studies and clinical trials. In addition, interviews were conducted with physicians or advanced practice providers experienced in prescribing these medications. Collected data indicated that JAK inhibitors were successful at treating selected conditions in adolescent populations. Effectiveness rates varied among medications; Upadacitinib showed the highest effectiveness average (82%). Common adverse effects associated with JAK inhibitor use were also noted. Overall, findings indicate that JAK inhibitors are effective in adolescent populations, but more research should be done regarding more areas these medications can help with.