Visceral Adiposity Threshold for Irreversible Hypothalamic-Pituitary-Gonadal Axis Suppression: The Aromatase-SHBG Saturation Hypothesis
Abstract
Obesity is strongly associated with male hypogonadism, yet weightloss yields inconsistent improvements in testosterone levels across individuals. Themechanisms underlying this heterogeneity remain poorly understood.
Fields of Study & Subjects
Hypothalamic control of reproductive hormones
Hormonal and reproductive studies
Regulation of Appetite and Obesity
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 5 January 2026
- Language
- EN