The Hepatic Zonation Paradox Why Zone 3 Cells Are Both Most Vulnerable and Most Regenerative
Abstract
Liver injury preferentially affects Zone 3 (pericentral) hepatocytes due tochronic hypoxia pO = 30-35 mmHg, yet these same cells exhibit the fastest regenerativeresponse post-injury. This paradox has remained mechanistically unexplained.
Fields of Study & Subjects
Liver physiology and pathology
Tissue Engineering and Regenerative Medicine
Organ Transplantation Techniques and Outcomes
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 5 January 2026
- Language
- EN