Phase Medicine Invariants of Biological Reintegrability under Radiative and Metabolic Stress

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Authors: Son David Bolduc
Cited by: 0

Abstract

This work presents a unified theoretical framework derived from Causal Theory (CT) for describing biological systems as open, non-equilibrium causal systems. It focuses on their ability to maintain structural reintegrability under irreversible perturbations, including ionizing radiation (Z) and environmental fluxes (X). Key contributions include: Identification of Point X, a threshold defining whether a system can reintegrate after perturbation. Formalization of the interplay between external perturbations, ingestion/environmental inputs, and internal structural topology. Analysis of empirical data (e.g., \textit{Arabidopsis thaliana}) showing low residual damage and high reintegration consistency associated with invariant geometric ratios. Distinction between descriptive observation and prescriptive claims: the framework does not suggest interventions or protections, but provides a mathematically falsifiable model for survival and structural stability under stress. Integration of radiobiology, genetics, and metabolic geometry under a single causal invariant formalism, laying the foundation for what is termed Phase Medicine.

Fields of Study & Subjects

Effects of Radiation Exposure Heat shock proteins research Morphological variations and asymmetry

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
6 January 2026
Language
EN
Document type
Preprint