05 02 Metastasis Base Architecture Hepatocellular Carcinoma HBV-related

HBV-associated HCC exhibits unique metastatic patterns driven by chronic viral inflammation, metabolic reprogramming, and tissue-specific microarchitectural adaptation . Traditional metastasis models focus on genetic driver mutations and immune evasion. Thisframework instead maps the geometric and metabolic architecture of metastatic ecosystems,identifying vulnerability thresholds where small perturbations could theoretically trigger catastrophic collapse .