09 02 Metastasis Base Architecture Lung Small Cell Lung Carcinoma SCLC
Abstract
Small cell lung cancer originates from pulmonary neuroendocrine (Kulchitsky) cells and exhibits unique biological characteristics: extreme proliferative rate, early metastatic spread (70%present with extensive-stage disease), initial chemosensitivity followed by rapid resistance, andprofound immunosuppression despite high mutational burden [1, 2]. Standard platinum-etoposidechemotherapy yields 60-70% initial response rates, yet median overall survival remains 9-11months with 2-year survival
Fields of Study & Subjects
Lung Cancer Research Studies
Neuroendocrine Tumor Research Advances
Chromatin Remodeling and Cancer
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 6 January 2026
- Language
- EN