10 02 Metastasis Base Architecture Head and Neck Carcinoma HPV-negative

Squamous cell carcinoma metastatic progression exhibits profound site-specific selectivity, with 64.3%of metastases localizing to squamo-columnar junction(SCJ) tissues despite their limited anatomical distribution . This preferential tropism cannot be explained by vascular anatomy alone and suggests fundamental biochemical compatibility between malignantkeratinocytes and transitional epithelial microenvironment. The framework Trie to map metastatic corelation and evolution dynamics the derived from this types of cells.