14 01 Base Architecture Colorectal Carcinoma MSI-H dMMR

Zenodo (CERN European Organization for Nuclear Research) 2026 Open access

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Authors: Ionut Alexandru Stefan
DOI: 10.5281/zenodo.18166649
Cited by: 0

Abstract

CMS1 (MSI-high) colorectal cancer represents a unique ecosystem where genomic instability (microsatellite instability) creates massive neoantigen burden, paradoxically triggering intense immuneinfiltration while maintaining tumor survival through incompletely understood mechanisms. Traditional analyses focus on isolated aspects—genomics OR immunology OR metabolism—missing theemergent properties arising from their integration.

Fields of Study & Subjects

Genetic factors in colorectal cancer Cancer Immunotherapy and Biomarkers Colorectal Cancer Treatments and Studies

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
6 January 2026
Language
EN